Can I take Magnesium with Vitamin D?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Magnesium
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Vitamin D

Short answer

We found no documented interaction between Magnesium and Vitamin D in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Magnesium

What it is: An essential mineral the body uses for muscle and nerve function, blood sugar and blood pressure control, and making protein, bone and DNA.

What the research says: Supplements may lower blood pressure slightly. People who get more magnesium from food tend to have a lower risk of type 2 diabetes, and it matters for bone health.

Cautions

  • Adults shouldn't take more than 350 mg a day from supplements unless a clinician advises it.
  • Too much from supplements can cause diarrhea, nausea and stomach cramps.

Medicines to check

  • Osteoporosis medicines (bisphosphonates) and some antibiotics: take them apart from magnesium
  • Diuretics
  • Long-term acid-reflux or ulcer medicines can lower magnesium levels

In Holitro: Magnesium Glycinate (133 mg per capsule)

Source: NIH Office of Dietary Supplements: Magnesium: Fact Sheet for Consumers (updated March 2021)

Vitamin D

What it is: A vitamin that helps the body absorb calcium and supports muscles, nerves and the immune system.

What the research says: Getting enough vitamin D and calcium helps protect against osteoporosis.

Cautions

  • Adults shouldn't exceed 4,000 IU (100 mcg) a day from all sources unless a clinician advises more. Too much can cause nausea, weakness, confusion and kidney stones.

Medicines to check

  • Statins: high-dose vitamin D may make them work less well
  • Steroids such as prednisone and the weight-loss drug orlistat lower vitamin D
  • Thiazide diuretics: with vitamin D, blood calcium could rise too high

Source: NIH Office of Dietary Supplements: Vitamin D: Fact Sheet for Consumers (updated November 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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