Short answer

We found no direct interaction between Alpha-lipoic acid and Ashwagandha in the sources below, but they share a caution.

Both have a note about diabetes medicines (see each one below).

Alpha-lipoic acid

What it is: An antioxidant the body makes and uses to produce energy.

What the research says: It's used for diabetic nerve pain, and studies suggest it can improve insulin sensitivity.

Cautions

• It can cause nausea, vomiting and low blood sugar.
• Rare cases of a condition causing sudden low blood sugar have been reported.

Medicines to check

• Diabetes medicines: it can lower blood sugar further

In Holitro: Alpha Lipoic Acid (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Alpha-Lipoic Acid (updated July 2026)

Ashwagandha

What it is: A plant root used in traditional Ayurvedic and Unani medicine, often called an adaptogen.

What the research says: Several small trials of 6 to 8 weeks found people felt less stress and anxiety, with doses around 500 to 600 mg a day working better than lower ones. A few small studies suggest a modest sleep benefit. It has not been studied thoroughly.

Cautions

• Well tolerated for up to about 3 months; long-term safety isn't known.
• Mild side effects can include upset stomach, loose stools, nausea and drowsiness.
• It has been linked to liver injury in some people.
• Not for people who are pregnant or breastfeeding, or who have prostate cancer.

Medicines to check

• Thyroid medicine (ashwagandha may affect how the thyroid works)
• Diabetes and blood-pressure medicines
• Sedatives
• Medicines that suppress the immune system

In Holitro: Ashwagandha (500 mg per capsule)

Source: NIH Office of Dietary Supplements: Ashwagandha: Fact Sheet for Consumers (updated December 2023)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.