Understanding the interactions, benefits, and safety of combining these two powerful supplements.
We found no documented interaction between Alpha-lipoic acid and Citrulline in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
What it is: An antioxidant the body makes and uses to produce energy.
What the research says: It's used for diabetic nerve pain, and studies suggest it can improve insulin sensitivity.
In Holitro: Alpha Lipoic Acid (500 mg per capsule)
Source: Memorial Sloan Kettering Cancer Center, About Herbs: Alpha-Lipoic Acid (updated July 2026)
What it is: An amino acid the body makes. The kidneys turn most of it into arginine, and then nitric oxide.
What the research says: Research on it as a performance supplement is limited and mixed.
In Holitro: Citrulline (500 mg per capsule)
Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Alpha Lipoic Acid is already lab-dosed and delivered daily in our Antioxidant Pack — one less bottle to manage.
Shop Antioxidant Pack