Short answer

We found no direct interaction between Alpha-lipoic acid and Vitamin B12 in the sources below, but they share a caution.

Both have a note about diabetes medicines (see each one below).

Alpha-lipoic acid

What it is: An antioxidant the body makes and uses to produce energy.

What the research says: It's used for diabetic nerve pain, and studies suggest it can improve insulin sensitivity.

Cautions

• It can cause nausea, vomiting and low blood sugar.
• Rare cases of a condition causing sudden low blood sugar have been reported.

Medicines to check

• Diabetes medicines: it can lower blood sugar further

In Holitro: Alpha Lipoic Acid (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Alpha-Lipoic Acid (updated July 2026)

Vitamin B12

What it is: A vitamin that keeps blood and nerve cells healthy and helps make DNA.

What the research says: B12 prevents a type of anemia that makes people tired and weak. People who take metformin or long-term acid reducers may absorb less of it.

Cautions

• It hasn't been shown to cause harm, even at high doses.

Medicines to check

• Metformin and acid-reducing medicines can lower B12 levels (the medicine affects the vitamin, not the other way round)

In Holitro: Vitamin B12 (1000 mcg per capsule)

Source: NIH Office of Dietary Supplements: Vitamin B12: Fact Sheet for Consumers (updated December 2023)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.