Short answer

We found no direct interaction between Arginine and Ashwagandha in the sources below, but they share a caution.

Both have a note about blood-pressure medicines (see each one below).

Arginine

What it is: An amino acid the body makes and gets from protein foods. The body turns it into nitric oxide, which widens blood vessels.

What the research says: There's little evidence it improves strength, exercise performance or recovery.

Cautions

• Up to 9 g a day seems safe for days to weeks; more can cause stomach upset.
• It can lower blood pressure slightly.

Medicines to check

• Blood-pressure medicines: arginine can lower blood pressure too

In Holitro: Arginine (500 mg per capsule)

Sources: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021); Memorial Sloan Kettering Cancer Center, About Herbs: Arginine (updated February 2022)

Ashwagandha

What it is: A plant root used in traditional Ayurvedic and Unani medicine, often called an adaptogen.

What the research says: Several small trials of 6 to 8 weeks found people felt less stress and anxiety, with doses around 500 to 600 mg a day working better than lower ones. A few small studies suggest a modest sleep benefit. It has not been studied thoroughly.

Cautions

• Well tolerated for up to about 3 months; long-term safety isn't known.
• Mild side effects can include upset stomach, loose stools, nausea and drowsiness.
• It has been linked to liver injury in some people.
• Not for people who are pregnant or breastfeeding, or who have prostate cancer.

Medicines to check

• Thyroid medicine (ashwagandha may affect how the thyroid works)
• Diabetes and blood-pressure medicines
• Sedatives
• Medicines that suppress the immune system

In Holitro: Ashwagandha (500 mg per capsule)

Source: NIH Office of Dietary Supplements: Ashwagandha: Fact Sheet for Consumers (updated December 2023)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.