Understanding the interactions, benefits, and safety of combining these two powerful supplements.
We found no documented interaction between Arginine and Hyaluronic acid in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
What it is: An amino acid the body makes and gets from protein foods. The body turns it into nitric oxide, which widens blood vessels.
What the research says: There's little evidence it improves strength, exercise performance or recovery.
In Holitro: Arginine (500 mg per capsule)
Sources: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021); Memorial Sloan Kettering Cancer Center, About Herbs: Arginine (updated February 2022)
What it is: A substance found naturally in skin and joints; taken by mouth for skin hydration.
What the research says: A review of 7 trials found better skin hydration and elasticity and shallower wrinkles. The trials were small and varied, so larger studies are needed.
In Holitro: Hyaluronic Acid (60 mg per capsule)
Source: PubMed review: Oral hyaluronic acid and skin: meta-analysis (2025) (updated September 2025)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Taking too much of one can blunt the absorption of the other.
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