Short answer

We found no documented interaction between Arginine and Zinc in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Arginine

What it is: An amino acid the body makes and gets from protein foods. The body turns it into nitric oxide, which widens blood vessels.

What the research says: There's little evidence it improves strength, exercise performance or recovery.

Cautions

• Up to 9 g a day seems safe for days to weeks; more can cause stomach upset.
• It can lower blood pressure slightly.

Medicines to check

• Blood-pressure medicines: arginine can lower blood pressure too

In Holitro: Arginine (500 mg per capsule)

Sources: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021); Memorial Sloan Kettering Cancer Center, About Herbs: Arginine (updated February 2022)

Zinc

What it is: An essential mineral for the immune system, wound healing, taste, and making DNA and proteins.

What the research says: Zinc is needed for normal immune function; it's commonly taken to make sure intake is adequate.

Cautions

• Adults shouldn't exceed 40 mg a day from all sources unless under medical care.
• Too much for a long time can lower copper levels and immunity.
• Very high doses can reduce magnesium absorption.

Medicines to check

• Quinolone and tetracycline antibiotics: take the antibiotic at least 2 hours before or 4 to 6 hours after zinc
• Penicillamine: take at least 1 hour apart
• Thiazide diuretics can lower zinc levels

In Holitro: Zinc (25 mg per capsule)

Source: NIH Office of Dietary Supplements: Zinc: Fact Sheet for Consumers (updated October 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.