Can I take BCAA with Glycine?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

BCAA
+
Glycine

Short answer

We found no documented interaction between BCAAs and Glycine in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

BCAAs (branched-chain amino acids)

What it is: Leucine, isoleucine and valine: amino acids from protein foods that muscles can use for energy.

What the research says: There's little evidence they help endurance. With weight training they might help muscle, but it isn't clear they do more than eating enough protein.

Cautions

  • A diet with enough protein already gives 10 to 20 g a day; up to another 20 g a day from supplements seems safe.

In Holitro: BCAA (600 mg per capsule)

Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)

Glycine

What it is: An amino acid the body makes; it's a building block of creatine, glutathione and collagen.

What the research says: Some studies suggest it may improve sleep quality and recovery, but reviews say more good human trials are needed.

Cautions

  • No major safety concerns are reported at supplement doses; human research is limited.

Medicines to check

  • Talk to your clinician if you take any medicine

In Holitro: Glycine (850 mg per capsule)

Sources: PubMed review: An Update of the Promise of Glycine Supplementation (Sports, 2024) (updated September 2024); PubMed review: Multifarious Beneficial Effect of Glycine: A Review (2017) (updated March 2017)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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