Can I take Calcium Citrate with Vitamin B12?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Calcium Citrate
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Vitamin B12

Short answer

We found no documented interaction between Calcium and Vitamin B12 in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Calcium

What it is: The body's most abundant mineral; it builds bones and teeth and helps muscles, nerves and blood vessels work.

What the research says: Calcium supports bone health, especially when diet falls short. Vitamin D helps the body absorb it.

Cautions

  • Upper limit from all sources: 2,500 mg a day for adults 19 to 50, and 2,000 mg from age 51.
  • Some research links very high intakes to heart disease and prostate cancer risk.

Medicines to check

  • Levothyroxine (thyroid medicine): keep doses apart
  • Quinolone antibiotics: keep at least 2 hours apart
  • Dolutegravir (HIV medicine) and lithium

In Holitro: Calcium Citrate (160 mg per capsule)

Source: NIH Office of Dietary Supplements: Calcium: Fact Sheet for Consumers (updated September 2023)

Vitamin B12

What it is: A vitamin that keeps blood and nerve cells healthy and helps make DNA.

What the research says: B12 prevents a type of anemia that makes people tired and weak. People who take metformin or long-term acid reducers may absorb less of it.

Cautions

  • It hasn't been shown to cause harm, even at high doses.

Medicines to check

  • Metformin and acid-reducing medicines can lower B12 levels (the medicine affects the vitamin, not the other way round)

In Holitro: Vitamin B12 (1000 mcg per capsule)

Source: NIH Office of Dietary Supplements: Vitamin B12: Fact Sheet for Consumers (updated December 2023)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack β€” free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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