Can I take Carnitine with Glycine?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Carnitine
+
Glycine

Short answer

We found no documented interaction between Carnitine and Glycine in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Carnitine

What it is: A nutrient the body makes and gets from meat; it helps turn food into energy.

What the research says: Healthy people make all they need. Results for dementia and other conditions are mixed.

Cautions

  • 3 g a day or more can cause nausea, cramps, diarrhea and a fishy body odor.
  • High amounts may cause muscle weakness in kidney disease and raise seizure risk in people with seizure disorders.

Medicines to check

  • Some anti-seizure medicines (phenobarbital, valproic acid) and long-term use of some antibiotics can lower carnitine levels

In Holitro: Carnitine (500 mg per capsule)

Source: NIH Office of Dietary Supplements: Carnitine: Fact Sheet for Consumers (updated May 2023)

Glycine

What it is: An amino acid the body makes; it's a building block of creatine, glutathione and collagen.

What the research says: Some studies suggest it may improve sleep quality and recovery, but reviews say more good human trials are needed.

Cautions

  • No major safety concerns are reported at supplement doses; human research is limited.

Medicines to check

  • Talk to your clinician if you take any medicine

In Holitro: Glycine (850 mg per capsule)

Sources: PubMed review: An Update of the Promise of Glycine Supplementation (Sports, 2024) (updated September 2024); PubMed review: Multifarious Beneficial Effect of Glycine: A Review (2017) (updated March 2017)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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