Can I take Choline with Saw Palmetto?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Choline
+
Saw Palmetto

Short answer

We found no documented interaction between Choline and Saw palmetto in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Choline

What it is: A nutrient the brain and nerves need for memory, mood and muscle control; it also builds cell membranes.

What the research says: Its effect on heart health is unclear: some research points to benefit and some to higher risk.

Cautions

  • Adults shouldn't exceed 3,500 mg a day.
  • Too much can cause fishy body odor, vomiting, sweating, low blood pressure and liver damage.

Medicines to check

  • It isn't known to interact with any medicines

In Holitro: Choline (420 mg per capsule)

Source: NIH Office of Dietary Supplements: Choline: Fact Sheet for Consumers (updated June 2022)

Saw palmetto

What it is: Berries from a small palm tree, sold mainly for prostate and hair concerns.

What the research says: A 2023 review of 27 studies found saw palmetto probably doesn't help urinary symptoms of an enlarged prostate. There isn't enough evidence for other uses, including hair loss.

Cautions

  • Well tolerated in studies lasting up to 3 years; side effects are mild (stomach upset, dizziness, headache).
  • It doesn't appear to change PSA test results.
  • May be unsafe in pregnancy or while breastfeeding.

Medicines to check

  • Talk to your clinician if you take any medicine

In Holitro: Saw Palmetto (650 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Saw Palmetto: Usefulness and Safety (updated April 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack β€” free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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