Short answer

We found no documented interaction between Citrulline and Glutamine in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Citrulline

What it is: An amino acid the body makes. The kidneys turn most of it into arginine, and then nitric oxide.

What the research says: Research on it as a performance supplement is limited and mixed.

Cautions

• There isn't enough research to know whether it's safe; some people report stomach discomfort.

In Holitro: Citrulline (500 mg per capsule)

Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)

Glutamine

What it is: An amino acid the body makes and uses for energy and to build protein.

What the research says: It has little or no benefit for strength or recovery. It's studied mainly in cancer care and after surgery.

Cautions

• Studies report no side effects at up to 45 g a day for several weeks; reported side effects elsewhere include headache and nausea.
• Don't confuse it with glutamate, which is a different substance.

In Holitro: Glutamine (750 mg per capsule)

Sources: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021); Memorial Sloan Kettering Cancer Center, About Herbs: Glutamine (updated September 2026)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.