Understanding the interactions, benefits, and safety of combining these two powerful supplements.
We found no documented interaction between Citrulline and Tyrosine in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
What it is: An amino acid the body makes. The kidneys turn most of it into arginine, and then nitric oxide.
What the research says: Research on it as a performance supplement is limited and mixed.
In Holitro: Citrulline (500 mg per capsule)
Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)
What it is: An amino acid the body uses to make dopamine and noradrenaline.
What the research says: It may help thinking during short, stressful or demanding tasks. Benefits for exercise or medical conditions appear small; reviews call the evidence weak.
In Holitro: Tyrosine (500 mg per capsule)
Sources: PubMed review: Tyrosine supplementation under stress or cognitive demands: review (2015) (updated August 2015); PubMed review: Tyrosine for mitigating stress: rapid evidence assessment (2015) (updated July 2015)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Taking too much of one can blunt the absorption of the other.
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