Can I take CoQ10 with Milk Thistle?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

CoQ10
+
Milk Thistle

Short answer

We found no documented interaction between CoQ10 and Milk thistle in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

CoQ10

What it is: A compound the body makes, found at high levels in the heart, liver and kidneys.

What the research says: Studies on heart disease are inconclusive. Overall, it doesn't seem to relieve muscle pain from statins, and it probably doesn't lower blood pressure meaningfully.

Cautions

  • No serious side effects reported; it can cause mild insomnia or stomach upset.

Medicines to check

  • Warfarin (blood thinner) and insulin
  • Some cancer treatments: check with your care team

In Holitro: CoQ10 (200 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Coenzyme Q10 (updated January 2019)

Milk thistle

What it is: A flowering plant whose extract, silymarin, is sold for liver health.

What the research says: There isn't enough good evidence to draw conclusions. Small studies suggest it may help blood sugar in type 2 diabetes; liver-disease trials have been conflicting.

Cautions

  • Usually well tolerated; it can cause bloating, nausea or gas.
  • It can trigger allergies in people allergic to ragweed, daisies or marigolds.
  • Little is known about use in pregnancy or breastfeeding.

Medicines to check

  • Talk to your clinician if you take any medicine

In Holitro: Milk Thistle (450 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Milk Thistle: Usefulness and Safety (updated February 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack β€” free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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