Can I take Glutamine with Rhodiola?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Glutamine
+
Rhodiola

Short answer

We found no documented interaction between Glutamine and Rhodiola in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Glutamine

What it is: An amino acid the body makes and uses for energy and to build protein.

What the research says: It has little or no benefit for strength or recovery. It's studied mainly in cancer care and after surgery.

Cautions

  • Studies report no side effects at up to 45 g a day for several weeks; reported side effects elsewhere include headache and nausea.
  • Don't confuse it with glutamate, which is a different substance.

In Holitro: Glutamine (750 mg per capsule)

Sources: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021); Memorial Sloan Kettering Cancer Center, About Herbs: Glutamine (updated September 2026)

Rhodiola

What it is: A plant from cold, high-altitude regions, sold for energy, stress, mood and focus.

What the research says: Not enough is known to say it helps with any health purpose.

Cautions

  • Possibly safe for up to 12 weeks; it can cause dizziness, headache, insomnia and dry mouth.
  • Little is known about use in pregnancy or breastfeeding.

Medicines to check

  • Losartan (a blood-pressure drug): interactions have been reported

In Holitro: Rhodiola (250 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Rhodiola: Usefulness and Safety (updated April 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

Stop Guessing Your Dosages.

Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Glutamine is already lab-dosed in our Gut Pack, and Rhodiola is in our Mood Support Pack — either way, that’s one less bottle to manage.

Shop Gut Pack