Short answer

We found no documented interaction between Lion's mane and Triphala in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Lion's mane

What it is: An edible mushroom used in East Asian medicine, sold for memory, mood and stress.

What the research says: Limited human studies suggest it may help memory and mood in some groups, such as older adults with mild memory problems. Most research is in the lab.

Cautions

• Reported side effects include stomach discomfort, nausea and skin rash.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Lion's Mane (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Lion's Mane Mushroom (updated June 2024)

Triphala

What it is: A traditional Ayurvedic blend of three dried fruits (amalaki, bibhitaki and haritaki), used mainly for digestion.

What the research says: It's traditionally used as a gentle laxative. Most other proposed benefits come from lab and animal studies, not good human trials.

Cautions

• There's little human safety research. Because it acts as a laxative, loose stools are possible.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Triphala (500 mg per capsule)

Source: PubMed review: Therapeutic Uses of Triphala in Ayurvedic Medicine (2017) (updated July 2017)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.