Short answer

We found no documented interaction between Alpha-lipoic acid and Saw palmetto in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Alpha-lipoic acid

What it is: An antioxidant the body makes and uses to produce energy.

What the research says: It's used for diabetic nerve pain, and studies suggest it can improve insulin sensitivity.

Cautions

• It can cause nausea, vomiting and low blood sugar.
• Rare cases of a condition causing sudden low blood sugar have been reported.

Medicines to check

• Diabetes medicines: it can lower blood sugar further

In Holitro: Alpha Lipoic Acid (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Alpha-Lipoic Acid (updated July 2026)

Saw palmetto

What it is: Berries from a small palm tree, sold mainly for prostate and hair concerns.

What the research says: A 2023 review of 27 studies found saw palmetto probably doesn't help urinary symptoms of an enlarged prostate. There isn't enough evidence for other uses, including hair loss.

Cautions

• Well tolerated in studies lasting up to 3 years; side effects are mild (stomach upset, dizziness, headache).
• It doesn't appear to change PSA test results.
• May be unsafe in pregnancy or while breastfeeding.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Saw Palmetto (650 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Saw Palmetto: Usefulness and Safety (updated April 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.