Can I take Alpha Lipoic Acid with Zinc?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Alpha Lipoic Acid
+
Zinc

Short answer

We found no documented interaction between Alpha-lipoic acid and Zinc in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Alpha-lipoic acid

What it is: An antioxidant the body makes and uses to produce energy.

What the research says: It's used for diabetic nerve pain, and studies suggest it can improve insulin sensitivity.

Cautions

  • It can cause nausea, vomiting and low blood sugar.
  • Rare cases of a condition causing sudden low blood sugar have been reported.

Medicines to check

  • Diabetes medicines: it can lower blood sugar further

In Holitro: Alpha Lipoic Acid (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Alpha-Lipoic Acid (updated July 2026)

Zinc

What it is: An essential mineral for the immune system, wound healing, taste, and making DNA and proteins.

What the research says: Zinc is needed for normal immune function; it's commonly taken to make sure intake is adequate.

Cautions

  • Adults shouldn't exceed 40 mg a day from all sources unless under medical care.
  • Too much for a long time can lower copper levels and immunity.
  • Very high doses can reduce magnesium absorption.

Medicines to check

  • Quinolone and tetracycline antibiotics: take the antibiotic at least 2 hours before or 4 to 6 hours after zinc
  • Penicillamine: take at least 1 hour apart
  • Thiazide diuretics can lower zinc levels

In Holitro: Zinc (25 mg per capsule)

Source: NIH Office of Dietary Supplements: Zinc: Fact Sheet for Consumers (updated October 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

Stop Guessing Your Dosages.

Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Alpha Lipoic Acid is already lab-dosed in our Antioxidant Pack, and Zinc is in our Immune Pack — either way, that’s one less bottle to manage.

Shop Antioxidant Pack