Understanding the interactions, benefits, and safety of combining these two powerful supplements.
We found no documented interaction between Arginine and Vitamin B12 in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
What it is: An amino acid the body makes and gets from protein foods. The body turns it into nitric oxide, which widens blood vessels.
What the research says: There's little evidence it improves strength, exercise performance or recovery.
In Holitro: Arginine (500 mg per capsule)
Sources: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021); Memorial Sloan Kettering Cancer Center, About Herbs: Arginine (updated February 2022)
What it is: A vitamin that keeps blood and nerve cells healthy and helps make DNA.
What the research says: B12 prevents a type of anemia that makes people tired and weak. People who take metformin or long-term acid reducers may absorb less of it.
In Holitro: Vitamin B12 (1000 mcg per capsule)
Source: NIH Office of Dietary Supplements: Vitamin B12: Fact Sheet for Consumers (updated December 2023)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Taking too much of one can blunt the absorption of the other.
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