Can I take Berberine with Boron?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Berberine
+
Boron

Short answer

We found no documented interaction between Berberine and Boron in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Berberine

What it is: A compound from plants such as barberry and goldenseal, used in Chinese and Ayurvedic medicine.

What the research says: It may lower cholesterol, triglycerides and blood sugar, but the effect may be small and lifestyle changes are still needed.

Cautions

  • Mild side effects can include appetite loss, upset stomach, diarrhea, constipation and rash.
  • Not for pregnancy or breastfeeding: it may harm newborns.

Medicines to check

  • Immune-suppressing drugs such as tacrolimus or cyclosporin: berberine may raise their levels
  • Some diabetes drugs (sulfonylureas)
  • Many prescription drugs processed by the liver: berberine may make them less effective
  • Bosutinib (a cancer drug)

In Holitro: Berberine 500mg (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Berberine (updated June 2023)

Boron

What it is: A trace mineral found in many foods. It isn't considered essential because no clear role in the body has been identified.

What the research says: It may play a part in bone health, calcium use and steroid hormones, but this isn't proven.

Cautions

  • Adults shouldn't exceed 20 mg a day.
  • Most boron poisonings come from swallowing boric acid or borax products, not food or supplements.

Medicines to check

  • No clinically relevant medicine interactions are known

In Holitro: Boron (10 mg per capsule)

Source: NIH Office of Dietary Supplements: Boron: Fact Sheet for Health Professionals (updated June 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack β€” free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Taking too much of one can blunt the absorption of the other.

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