Understanding the interactions, benefits, and safety of combining these two powerful supplements.
We found no documented interaction between Berberine and Hyaluronic acid in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
What it is: A compound from plants such as barberry and goldenseal, used in Chinese and Ayurvedic medicine.
What the research says: It may lower cholesterol, triglycerides and blood sugar, but the effect may be small and lifestyle changes are still needed.
In Holitro: Berberine 500mg (500 mg per capsule)
Source: Memorial Sloan Kettering Cancer Center, About Herbs: Berberine (updated June 2023)
What it is: A substance found naturally in skin and joints; taken by mouth for skin hydration.
What the research says: A review of 7 trials found better skin hydration and elasticity and shallower wrinkles. The trials were small and varied, so larger studies are needed.
In Holitro: Hyaluronic Acid (60 mg per capsule)
Source: PubMed review: Oral hyaluronic acid and skin: meta-analysis (2025) (updated September 2025)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Taking too much of one can blunt the absorption of the other.
Holitro completely solves this. We combine synergistic ingredients into one perfectly dosed daily pack, scientifically formulated for maximum absorption.
