Understanding the interactions, benefits, and safety of combining these two powerful supplements.
We found no documented interaction between Berberine and Milk thistle in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
What it is: A compound from plants such as barberry and goldenseal, used in Chinese and Ayurvedic medicine.
What the research says: It may lower cholesterol, triglycerides and blood sugar, but the effect may be small and lifestyle changes are still needed.
In Holitro: Berberine 500mg (500 mg per capsule)
Source: Memorial Sloan Kettering Cancer Center, About Herbs: Berberine (updated June 2023)
What it is: A flowering plant whose extract, silymarin, is sold for liver health.
What the research says: There isn't enough good evidence to draw conclusions. Small studies suggest it may help blood sugar in type 2 diabetes; liver-disease trials have been conflicting.
In Holitro: Milk Thistle (450 mg per capsule)
Source: NIH National Center for Complementary and Integrative Health: Milk Thistle: Usefulness and Safety (updated February 2025)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Taking too much of one can blunt the absorption of the other.
Holitro completely solves this. We combine synergistic ingredients into one perfectly dosed daily pack, scientifically formulated for maximum absorption.
