Short answer

We found no documented interaction between Berberine and Omega-3 in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Berberine

What it is: A compound from plants such as barberry and goldenseal, used in Chinese and Ayurvedic medicine.

What the research says: It may lower cholesterol, triglycerides and blood sugar, but the effect may be small and lifestyle changes are still needed.

Cautions

• Mild side effects can include appetite loss, upset stomach, diarrhea, constipation and rash.
• Not for pregnancy or breastfeeding: it may harm newborns.

Medicines to check

• Immune-suppressing drugs such as tacrolimus or cyclosporin: berberine may raise their levels
• Some diabetes drugs (sulfonylureas)
• Many prescription drugs processed by the liver: berberine may make them less effective
• Bosutinib (a cancer drug)

In Holitro: Berberine 500mg (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Berberine (updated June 2023)

Omega-3 (fish oil)

What it is: Fats (EPA and DHA) found in fish that are part of every cell membrane and matter for the heart, brain and eyes.

What the research says: EPA and DHA lower triglycerides. Heart experts recommend eating fish; they don't recommend omega-3 supplements for people at low heart risk.

Cautions

• The FDA advises no more than 5 g a day of EPA plus DHA from supplements.
• Side effects are usually mild: fishy taste, heartburn, nausea, loose stools.

Medicines to check

• Warfarin and other blood thinners: high doses may raise bleeding risk

In Holitro: Omega 3 1000mg (1000 mg per capsule)

Source: NIH Office of Dietary Supplements: Omega-3 Fatty Acids: Fact Sheet for Consumers (updated July 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.