Short answer

We found no direct interaction between Berberine and Resveratrol in the sources below, but they share a caution.

Both may change how your body processes some prescription medicines.

Berberine

What it is: A compound from plants such as barberry and goldenseal, used in Chinese and Ayurvedic medicine.

What the research says: It may lower cholesterol, triglycerides and blood sugar, but the effect may be small and lifestyle changes are still needed.

Cautions

• Mild side effects can include appetite loss, upset stomach, diarrhea, constipation and rash.
• Not for pregnancy or breastfeeding: it may harm newborns.

Medicines to check

• Immune-suppressing drugs such as tacrolimus or cyclosporin: berberine may raise their levels
• Some diabetes drugs (sulfonylureas)
• Many prescription drugs processed by the liver: berberine may make them less effective
• Bosutinib (a cancer drug)

In Holitro: Berberine 500mg (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Berberine (updated June 2023)

Resveratrol

What it is: A compound found in grapes, red wine, peanuts and berries, sold as an anti-aging supplement.

What the research says: Anti-aging effects have been seen in yeast, not people. Reviews and recent trials found no benefit for memory or thinking.

Cautions

• High doses can cause nausea, gas, stomach pain and diarrhea.

Medicines to check

• Blood thinners and antiplatelet drugs: it may raise bleeding risk
• Some prescription drugs processed by the liver

In Holitro: Resveratrol (250 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Resveratrol (updated February 2023)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.