Short answer

We found no documented interaction between Berberine and Turmeric in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Berberine

What it is: A compound from plants such as barberry and goldenseal, used in Chinese and Ayurvedic medicine.

What the research says: It may lower cholesterol, triglycerides and blood sugar, but the effect may be small and lifestyle changes are still needed.

Cautions

• Mild side effects can include appetite loss, upset stomach, diarrhea, constipation and rash.
• Not for pregnancy or breastfeeding: it may harm newborns.

Medicines to check

• Immune-suppressing drugs such as tacrolimus or cyclosporin: berberine may raise their levels
• Some diabetes drugs (sulfonylureas)
• Many prescription drugs processed by the liver: berberine may make them less effective
• Bosutinib (a cancer drug)

In Holitro: Berberine 500mg (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Berberine (updated June 2023)

Turmeric

What it is: A spice root in the ginger family; curcumin is its best-known active compound.

What the research says: There isn't enough evidence to say turmeric helps any health condition. Early evidence for knee osteoarthritis pain and stiffness is positive but needs better studies.

Cautions

• Standard turmeric or curcumin is likely safe in recommended amounts for 2 to 3 months.
• It can cause nausea, reflux, stomach upset, diarrhea or constipation.
• Liver damage has been reported with curcumin made to absorb better. Stop and see a clinician if you notice tiredness, dark urine or yellowing skin.
• May be unsafe in pregnancy.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Turmeric (700 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Turmeric: Usefulness and Safety (updated April 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.