Short answer

We found no documented interaction between Calcium and B-complex in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Calcium

What it is: The body's most abundant mineral; it builds bones and teeth and helps muscles, nerves and blood vessels work.

What the research says: Calcium supports bone health, especially when diet falls short. Vitamin D helps the body absorb it.

Cautions

• Upper limit from all sources: 2,500 mg a day for adults 19 to 50, and 2,000 mg from age 51.
• Some research links very high intakes to heart disease and prostate cancer risk.

Medicines to check

• Levothyroxine (thyroid medicine): keep doses apart
• Quinolone antibiotics: keep at least 2 hours apart
• Dolutegravir (HIV medicine) and lithium

In Holitro: Calcium Citrate (160 mg per capsule)

Source: NIH Office of Dietary Supplements: Calcium: Fact Sheet for Consumers (updated September 2023)

B-complex (active forms)

What it is: A mix of B vitamins in their active forms.

What the research says: B vitamins help turn food into energy and keep blood and nerve cells healthy; a supplement helps if your diet falls short.

Cautions

• High-dose folate can hide a vitamin B12 deficiency.
• Taking a lot of vitamin B6 for a year or more can cause nerve damage.
• Niacin at 30 mg or more can cause flushing and itching.

Medicines to check

• Methotrexate: folate can interfere with it
• Anti-seizure medicines (folate and vitamin B6 notes)

In Holitro: Methyl B-Complex

Sources: NIH Office of Dietary Supplements: Folate: Fact Sheet for Consumers (updated November 2022); NIH Office of Dietary Supplements: Vitamin B6: Fact Sheet for Consumers (updated June 2023); NIH Office of Dietary Supplements: Niacin: Fact Sheet for Consumers (updated March 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.