Short answer

We found no documented interaction between Choline and Rhodiola in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Choline

What it is: A nutrient the brain and nerves need for memory, mood and muscle control; it also builds cell membranes.

What the research says: Its effect on heart health is unclear: some research points to benefit and some to higher risk.

Cautions

• Adults shouldn't exceed 3,500 mg a day.
• Too much can cause fishy body odor, vomiting, sweating, low blood pressure and liver damage.

Medicines to check

• It isn't known to interact with any medicines

In Holitro: Choline (420 mg per capsule)

Source: NIH Office of Dietary Supplements: Choline: Fact Sheet for Consumers (updated June 2022)

Rhodiola

What it is: A plant from cold, high-altitude regions, sold for energy, stress, mood and focus.

What the research says: Not enough is known to say it helps with any health purpose.

Cautions

• Possibly safe for up to 12 weeks; it can cause dizziness, headache, insomnia and dry mouth.
• Little is known about use in pregnancy or breastfeeding.

Medicines to check

• Losartan (a blood-pressure drug): interactions have been reported

In Holitro: Rhodiola (250 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Rhodiola: Usefulness and Safety (updated April 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.