Short answer

We found no documented interaction between Chromium and Lion's mane in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Chromium

What it is: A mineral found in many foods that may help the body use carbohydrates, fats and protein.

What the research says: Studies on blood sugar are mixed. The American Diabetes Association doesn't recommend it because it has no clear benefit.

Cautions

• No harm has been shown, but research is limited. People with kidney or liver disease should be careful with high amounts.

Medicines to check

• Insulin, metformin and other diabetes medicines: chromium may push blood sugar too low
• Levothyroxine (thyroid medicine): chromium may reduce how much is absorbed

In Holitro: Chromium (1000 mcg per capsule)

Source: NIH Office of Dietary Supplements: Chromium: Fact Sheet for Consumers (updated March 2021)

Lion's mane

What it is: An edible mushroom used in East Asian medicine, sold for memory, mood and stress.

What the research says: Limited human studies suggest it may help memory and mood in some groups, such as older adults with mild memory problems. Most research is in the lab.

Cautions

• Reported side effects include stomach discomfort, nausea and skin rash.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Lion's Mane (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Lion's Mane Mushroom (updated June 2024)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.