Short answer

We found no documented interaction between Chromium and NAC in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Chromium

What it is: A mineral found in many foods that may help the body use carbohydrates, fats and protein.

What the research says: Studies on blood sugar are mixed. The American Diabetes Association doesn't recommend it because it has no clear benefit.

Cautions

• No harm has been shown, but research is limited. People with kidney or liver disease should be careful with high amounts.

Medicines to check

• Insulin, metformin and other diabetes medicines: chromium may push blood sugar too low
• Levothyroxine (thyroid medicine): chromium may reduce how much is absorbed

In Holitro: Chromium (1000 mcg per capsule)

Source: NIH Office of Dietary Supplements: Chromium: Fact Sheet for Consumers (updated March 2021)

NAC (N-acetylcysteine)

What it is: An antioxidant that's both a hospital medicine (for acetaminophen overdose) and a supplement.

What the research says: As a medicine it treats acetaminophen poisoning. As a supplement, results for lung conditions and as an add-on for depression are mixed.

Cautions

• It can cause stomach upset, nausea, diarrhea, tiredness or rash; less often low blood pressure or headache.

Medicines to check

• Nitroglycerin: don't combine (severe headaches, lower blood pressure)
• Antidepressants: animal studies suggest NAC may strengthen their effect
• Cancer treatment: check with your care team

In Holitro: NAC (600 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: N-Acetylcysteine (updated October 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.