Short answer

We found no documented interaction between Chromium and Zinc in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Chromium

What it is: A mineral found in many foods that may help the body use carbohydrates, fats and protein.

What the research says: Studies on blood sugar are mixed. The American Diabetes Association doesn't recommend it because it has no clear benefit.

Cautions

• No harm has been shown, but research is limited. People with kidney or liver disease should be careful with high amounts.

Medicines to check

• Insulin, metformin and other diabetes medicines: chromium may push blood sugar too low
• Levothyroxine (thyroid medicine): chromium may reduce how much is absorbed

In Holitro: Chromium (1000 mcg per capsule)

Source: NIH Office of Dietary Supplements: Chromium: Fact Sheet for Consumers (updated March 2021)

Zinc

What it is: An essential mineral for the immune system, wound healing, taste, and making DNA and proteins.

What the research says: Zinc is needed for normal immune function; it's commonly taken to make sure intake is adequate.

Cautions

• Adults shouldn't exceed 40 mg a day from all sources unless under medical care.
• Too much for a long time can lower copper levels and immunity.
• Very high doses can reduce magnesium absorption.

Medicines to check

• Quinolone and tetracycline antibiotics: take the antibiotic at least 2 hours before or 4 to 6 hours after zinc
• Penicillamine: take at least 1 hour apart
• Thiazide diuretics can lower zinc levels

In Holitro: Zinc (25 mg per capsule)

Source: NIH Office of Dietary Supplements: Zinc: Fact Sheet for Consumers (updated October 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.