Can I take Citrulline with Resveratrol?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Citrulline
+
Resveratrol

Short answer

We found no documented interaction between Citrulline and Resveratrol in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Citrulline

What it is: An amino acid the body makes. The kidneys turn most of it into arginine, and then nitric oxide.

What the research says: Research on it as a performance supplement is limited and mixed.

Cautions

  • There isn't enough research to know whether it's safe; some people report stomach discomfort.

In Holitro: Citrulline (500 mg per capsule)

Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)

Resveratrol

What it is: A compound found in grapes, red wine, peanuts and berries, sold as an anti-aging supplement.

What the research says: Anti-aging effects have been seen in yeast, not people. Reviews and recent trials found no benefit for memory or thinking.

Cautions

  • High doses can cause nausea, gas, stomach pain and diarrhea.

Medicines to check

  • Blood thinners and antiplatelet drugs: it may raise bleeding risk
  • Some prescription drugs processed by the liver

In Holitro: Resveratrol (250 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Resveratrol (updated February 2023)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

Stop Guessing Your Dosages.

Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Resveratrol is already lab-dosed and delivered daily in our Antioxidant Pack — one less bottle to manage.

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