Understanding the interactions, benefits, and safety of combining these two powerful supplements.
We found no documented interaction between Citrulline and Rhodiola in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
What it is: An amino acid the body makes. The kidneys turn most of it into arginine, and then nitric oxide.
What the research says: Research on it as a performance supplement is limited and mixed.
In Holitro: Citrulline (500 mg per capsule)
Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)
What it is: A plant from cold, high-altitude regions, sold for energy, stress, mood and focus.
What the research says: Not enough is known to say it helps with any health purpose.
In Holitro: Rhodiola (250 mg per capsule)
Source: NIH National Center for Complementary and Integrative Health: Rhodiola: Usefulness and Safety (updated April 2025)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Rhodiola is already lab-dosed and delivered daily in our Mood Support Pack — one less bottle to manage.
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