Short answer

We found no direct interaction between CoQ10 and NAC in the sources below, but they share a caution.

Both have a note about cancer treatment; check with your care team.

CoQ10

What it is: A compound the body makes, found at high levels in the heart, liver and kidneys.

What the research says: Studies on heart disease are inconclusive. Overall, it doesn't seem to relieve muscle pain from statins, and it probably doesn't lower blood pressure meaningfully.

Cautions

• No serious side effects reported; it can cause mild insomnia or stomach upset.

Medicines to check

• Warfarin (blood thinner) and insulin
• Some cancer treatments: check with your care team

In Holitro: CoQ10 (200 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Coenzyme Q10 (updated January 2019)

NAC (N-acetylcysteine)

What it is: An antioxidant that's both a hospital medicine (for acetaminophen overdose) and a supplement.

What the research says: As a medicine it treats acetaminophen poisoning. As a supplement, results for lung conditions and as an add-on for depression are mixed.

Cautions

• It can cause stomach upset, nausea, diarrhea, tiredness or rash; less often low blood pressure or headache.

Medicines to check

• Nitroglycerin: don't combine (severe headaches, lower blood pressure)
• Antidepressants: animal studies suggest NAC may strengthen their effect
• Cancer treatment: check with your care team

In Holitro: NAC (600 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: N-Acetylcysteine (updated October 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.