Short answer

We found no documented interaction between Cordyceps and Lion's mane in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Cordyceps

What it is: A fungus that grows on moth caterpillars, used in traditional Chinese medicine for energy and immunity.

What the research says: Some studies looked at kidney function in transplant and diabetes patients, but reviews question the quality of the evidence. Most research is in the lab.

Cautions

• No major side effects have been reported.

Medicines to check

• Insulin and other blood-sugar-lowering medicines: cordyceps may lower blood sugar too
• Blood thinners such as warfarin: it may raise bleeding risk

In Holitro: Cordyceps (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Cordyceps (updated February 2022)

Lion's mane

What it is: An edible mushroom used in East Asian medicine, sold for memory, mood and stress.

What the research says: Limited human studies suggest it may help memory and mood in some groups, such as older adults with mild memory problems. Most research is in the lab.

Cautions

• Reported side effects include stomach discomfort, nausea and skin rash.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Lion's Mane (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Lion's Mane Mushroom (updated June 2024)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.