Short answer

We found no documented interaction between Cordyceps and NR in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Cordyceps

What it is: A fungus that grows on moth caterpillars, used in traditional Chinese medicine for energy and immunity.

What the research says: Some studies looked at kidney function in transplant and diabetes patients, but reviews question the quality of the evidence. Most research is in the lab.

Cautions

• No major side effects have been reported.

Medicines to check

• Insulin and other blood-sugar-lowering medicines: cordyceps may lower blood sugar too
• Blood thinners such as warfarin: it may raise bleeding risk

In Holitro: Cordyceps (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Cordyceps (updated February 2022)

NR (nicotinamide riboside)

What it is: A form of vitamin B3 that the body uses to make NAD+, a molecule involved in energy production.

What the research says: It reliably raises NAD+ levels and was well tolerated for weeks to months in trials, but effects on health and aging have been mixed or absent.

Cautions

• Generally well tolerated in trials; long-term data are limited.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: NR (500 mg per capsule)

Source: PubMed review: NAD+ supplementation for anti-aging: systematic review (2026) (updated February 2026)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.