Can I take Creatine with Milk Thistle?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Creatine
+
Milk Thistle

Short answer

We found no documented interaction between Creatine and Milk thistle in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Creatine

What it is: A compound stored in muscle that supplies energy for short, intense effort. The body makes about 1 g a day.

What the research says: Creatine can increase strength and power for repeated short bursts like sprinting and lifting, but helps little with endurance exercise. Studies typically used 3 to 5 g a day after a loading phase; creatine monohydrate is the most studied form.

Cautions

  • Considered safe for healthy adults for weeks to months, and it seems safe for years.
  • It usually causes some weight gain from water retention; rarely cramps or stomach upset.

In Holitro: Creatine (750 mg per capsule)

Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)

Milk thistle

What it is: A flowering plant whose extract, silymarin, is sold for liver health.

What the research says: There isn't enough good evidence to draw conclusions. Small studies suggest it may help blood sugar in type 2 diabetes; liver-disease trials have been conflicting.

Cautions

  • Usually well tolerated; it can cause bloating, nausea or gas.
  • It can trigger allergies in people allergic to ragweed, daisies or marigolds.
  • Little is known about use in pregnancy or breastfeeding.

Medicines to check

  • Talk to your clinician if you take any medicine

In Holitro: Milk Thistle (450 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Milk Thistle: Usefulness and Safety (updated February 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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