Can I take Creatine with Vitamin C?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Creatine
+
Vitamin C

Short answer

We found no documented interaction between Creatine and Vitamin C in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Creatine

What it is: A compound stored in muscle that supplies energy for short, intense effort. The body makes about 1 g a day.

What the research says: Creatine can increase strength and power for repeated short bursts like sprinting and lifting, but helps little with endurance exercise. Studies typically used 3 to 5 g a day after a loading phase; creatine monohydrate is the most studied form.

Cautions

  • Considered safe for healthy adults for weeks to months, and it seems safe for years.
  • It usually causes some weight gain from water retention; rarely cramps or stomach upset.

In Holitro: Creatine (750 mg per capsule)

Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)

Vitamin C

What it is: An antioxidant vitamin the body needs to make collagen, absorb iron from plant foods and support the immune system.

What the research says: Vitamin C is essential; supplements make sure you get enough if your diet falls short.

Cautions

  • Adults shouldn't exceed 2,000 mg a day; too much can cause diarrhea, nausea and cramps.
  • People with hemochromatosis should avoid high doses.

Medicines to check

  • Chemotherapy and radiation: check with your care team first
  • In one study, antioxidants including vitamin C reduced the benefit of a statin plus niacin

In Holitro: Vitamin C (1000 mg per capsule)

Source: NIH Office of Dietary Supplements: Vitamin C: Fact Sheet for Consumers (updated March 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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