Can I take DIM with Glutamine?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

DIM
+
Glutamine

Short answer

We found no documented interaction between DIM and Glutamine in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

DIM (diindolylmethane)

What it is: A compound formed from vegetables like broccoli and cabbage, sold for estrogen balance.

What the research says: It changes how estrogen is broken down, and lab studies suggest anticancer effects, but human data are limited. There's no evidence for 'detox' claims.

Cautions

  • Not for pregnancy, trying to conceive or breastfeeding, because of possible hormone effects.
  • Rare reports include vision problems after very high use, and rash.

Medicines to check

  • Birth control pills: check with a clinician first
  • Many prescription drugs processed by the liver: DIM may make them less effective

In Holitro: DIM (300 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Diindolylmethane (updated December 2023)

Glutamine

What it is: An amino acid the body makes and uses for energy and to build protein.

What the research says: It has little or no benefit for strength or recovery. It's studied mainly in cancer care and after surgery.

Cautions

  • Studies report no side effects at up to 45 g a day for several weeks; reported side effects elsewhere include headache and nausea.
  • Don't confuse it with glutamate, which is a different substance.

In Holitro: Glutamine (750 mg per capsule)

Sources: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021); Memorial Sloan Kettering Cancer Center, About Herbs: Glutamine (updated September 2026)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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