Short answer

We found no documented interaction between DIM and Magnesium in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

DIM (diindolylmethane)

What it is: A compound formed from vegetables like broccoli and cabbage, sold for estrogen balance.

What the research says: It changes how estrogen is broken down, and lab studies suggest anticancer effects, but human data are limited. There's no evidence for 'detox' claims.

Cautions

• Not for pregnancy, trying to conceive or breastfeeding, because of possible hormone effects.
• Rare reports include vision problems after very high use, and rash.

Medicines to check

• Birth control pills: check with a clinician first
• Many prescription drugs processed by the liver: DIM may make them less effective

In Holitro: DIM (300 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Diindolylmethane (updated December 2023)

Magnesium

What it is: An essential mineral the body uses for muscle and nerve function, blood sugar and blood pressure control, and making protein, bone and DNA.

What the research says: Supplements may lower blood pressure slightly. People who get more magnesium from food tend to have a lower risk of type 2 diabetes, and it matters for bone health.

Cautions

• Adults shouldn't take more than 350 mg a day from supplements unless a clinician advises it.
• Too much from supplements can cause diarrhea, nausea and stomach cramps.

Medicines to check

• Osteoporosis medicines (bisphosphonates) and some antibiotics: take them apart from magnesium
• Diuretics
• Long-term acid-reflux or ulcer medicines can lower magnesium levels

In Holitro: Magnesium Glycinate (133 mg per capsule)

Source: NIH Office of Dietary Supplements: Magnesium: Fact Sheet for Consumers (updated March 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.