Short answer

We found no direct interaction between Green tea extract and Vitamin C in the sources below, but they share a caution.

Both have a note about cholesterol-lowering statins.

Green tea extract

What it is: A concentrated extract of green tea leaves, rich in catechins such as EGCG. It contains caffeine.

What the research says: Catechins and caffeine may have a modest effect on weight, and it lowered LDL cholesterol a little. Cancer results are inconsistent.

Cautions

• Extracts can cause nausea, constipation, stomach discomfort and higher blood pressure.
• Liver injury has been reported, mainly with extract capsules; a gene variant found in 5 to 15% of Americans raises the risk.

Medicines to check

• Nadolol (a beta-blocker): green tea can lower its levels
• Atorvastatin (a statin) and raloxifene (an osteoporosis drug)

In Holitro: Green Tea Extract 500mg (500 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Green Tea: Usefulness and Safety (updated February 2025)

Vitamin C

What it is: An antioxidant vitamin the body needs to make collagen, absorb iron from plant foods and support the immune system.

What the research says: Vitamin C is essential; supplements make sure you get enough if your diet falls short.

Cautions

• Adults shouldn't exceed 2,000 mg a day; too much can cause diarrhea, nausea and cramps.
• People with hemochromatosis should avoid high doses.

Medicines to check

• Chemotherapy and radiation: check with your care team first
• In one study, antioxidants including vitamin C reduced the benefit of a statin plus niacin

In Holitro: Vitamin C (1000 mg per capsule)

Source: NIH Office of Dietary Supplements: Vitamin C: Fact Sheet for Consumers (updated March 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.