Can I take L-Theanine with Probiotics?
Understanding the interactions, benefits, and safety of combining these two powerful supplements.
Short answer
We found no documented interaction between L-theanine and Probiotic in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.
L-theanine
What it is: An amino acid found in green tea, taken for calm and sleep.
What the research says: Small studies suggest it may improve sleep; results for anxiety are mixed.
Cautions
- No side effects have been reported for the supplement.
- It may not be safe in pregnancy or while breastfeeding.
Medicines to check
- Sleep medicines and sedatives (such as lorazepam, diazepam or zolpidem): may add to drowsiness
In Holitro: Theanine 200mg (200 mg per capsule)
Source: Memorial Sloan Kettering Cancer Center, About Herbs: L-Theanine (updated July 2026)
Probiotic
What it is: Live microorganisms, mostly bacteria, that may benefit health when taken in large enough amounts. They work mainly in the gut.
What the research says: Effects depend on the specific strain, and many probiotic products haven't been studied.
Cautions
- Probiotics have a long record of safe use; healthy people may get some gas.
- They may not be safe for people who are seriously ill or have a weakened immune system.
In Holitro: 10B Probiotic
Source: NIH Office of Dietary Supplements: Probiotics: Fact Sheet for Consumers (updated November 2025)
Check with your doctor or pharmacist, especially if you take medication.
Check your stack — freeEducational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.
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