Short answer

We found no documented interaction between Magnesium and Rhodiola in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Magnesium

What it is: An essential mineral the body uses for muscle and nerve function, blood sugar and blood pressure control, and making protein, bone and DNA.

What the research says: Supplements may lower blood pressure slightly. People who get more magnesium from food tend to have a lower risk of type 2 diabetes, and it matters for bone health.

Cautions

• Adults shouldn't take more than 350 mg a day from supplements unless a clinician advises it.
• Too much from supplements can cause diarrhea, nausea and stomach cramps.

Medicines to check

• Osteoporosis medicines (bisphosphonates) and some antibiotics: take them apart from magnesium
• Diuretics
• Long-term acid-reflux or ulcer medicines can lower magnesium levels

In Holitro: Magnesium Glycinate (133 mg per capsule)

Source: NIH Office of Dietary Supplements: Magnesium: Fact Sheet for Consumers (updated March 2021)

Rhodiola

What it is: A plant from cold, high-altitude regions, sold for energy, stress, mood and focus.

What the research says: Not enough is known to say it helps with any health purpose.

Cautions

• Possibly safe for up to 12 weeks; it can cause dizziness, headache, insomnia and dry mouth.
• Little is known about use in pregnancy or breastfeeding.

Medicines to check

• Losartan (a blood-pressure drug): interactions have been reported

In Holitro: Rhodiola (250 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Rhodiola: Usefulness and Safety (updated April 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.