Can I take Melatonin with Tyrosine?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Melatonin
+
Tyrosine

Short answer

We found no documented interaction between Melatonin and Tyrosine in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Melatonin

What it is: A hormone the brain makes in the dark that helps set your sleep-wake clock.

What the research says: It may help with jet lag and some circadian sleep problems. Sleep-medicine guidelines say there isn't enough evidence to recommend it for chronic insomnia.

Cautions

  • Short-term use seems safe for most people; long-term safety isn't known.
  • Older adults may feel drowsy the next day.

Medicines to check

  • Blood thinners and epilepsy: use only under medical supervision

Source: NIH National Center for Complementary and Integrative Health: Melatonin: What You Need To Know (updated May 2024)

Tyrosine

What it is: An amino acid the body uses to make dopamine and noradrenaline.

What the research says: It may help thinking during short, stressful or demanding tasks. Benefits for exercise or medical conditions appear small; reviews call the evidence weak.

Cautions

  • The reviews we used don't report safety data.

Medicines to check

  • Talk to your clinician if you take any medicine

In Holitro: Tyrosine (500 mg per capsule)

Sources: PubMed review: Tyrosine supplementation under stress or cognitive demands: review (2015) (updated August 2015); PubMed review: Tyrosine for mitigating stress: rapid evidence assessment (2015) (updated July 2015)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack β€” free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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