Can I take Methyl B-Complex with NR?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Methyl B-Complex
+
NR

Short answer

We found no documented interaction between B-complex and NR in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

B-complex (active forms)

What it is: A mix of B vitamins in their active forms.

What the research says: B vitamins help turn food into energy and keep blood and nerve cells healthy; a supplement helps if your diet falls short.

Cautions

  • High-dose folate can hide a vitamin B12 deficiency.
  • Taking a lot of vitamin B6 for a year or more can cause nerve damage.
  • Niacin at 30 mg or more can cause flushing and itching.

Medicines to check

  • Methotrexate: folate can interfere with it
  • Anti-seizure medicines (folate and vitamin B6 notes)

In Holitro: Methyl B-Complex

Sources: NIH Office of Dietary Supplements: Folate: Fact Sheet for Consumers (updated November 2022); NIH Office of Dietary Supplements: Vitamin B6: Fact Sheet for Consumers (updated June 2023); NIH Office of Dietary Supplements: Niacin: Fact Sheet for Consumers (updated March 2021)

NR (nicotinamide riboside)

What it is: A form of vitamin B3 that the body uses to make NAD+, a molecule involved in energy production.

What the research says: It reliably raises NAD+ levels and was well tolerated for weeks to months in trials, but effects on health and aging have been mixed or absent.

Cautions

  • Generally well tolerated in trials; long-term data are limited.

Medicines to check

  • Talk to your clinician if you take any medicine

In Holitro: NR (500 mg per capsule)

Source: PubMed review: NAD+ supplementation for anti-aging: systematic review (2026) (updated February 2026)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

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Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Methyl B-Complex is already lab-dosed and delivered daily in our Mood Support Pack — one less bottle to manage.

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