Short answer

We found no documented interaction between Milk thistle and Triphala in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Milk thistle

What it is: A flowering plant whose extract, silymarin, is sold for liver health.

What the research says: There isn't enough good evidence to draw conclusions. Small studies suggest it may help blood sugar in type 2 diabetes; liver-disease trials have been conflicting.

Cautions

• Usually well tolerated; it can cause bloating, nausea or gas.
• It can trigger allergies in people allergic to ragweed, daisies or marigolds.
• Little is known about use in pregnancy or breastfeeding.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Milk Thistle (450 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Milk Thistle: Usefulness and Safety (updated February 2025)

Triphala

What it is: A traditional Ayurvedic blend of three dried fruits (amalaki, bibhitaki and haritaki), used mainly for digestion.

What the research says: It's traditionally used as a gentle laxative. Most other proposed benefits come from lab and animal studies, not good human trials.

Cautions

• There's little human safety research. Because it acts as a laxative, loose stools are possible.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Triphala (500 mg per capsule)

Source: PubMed review: Therapeutic Uses of Triphala in Ayurvedic Medicine (2017) (updated July 2017)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.