Short answer

We found no documented interaction between NR and Omega-3 in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

NR (nicotinamide riboside)

What it is: A form of vitamin B3 that the body uses to make NAD+, a molecule involved in energy production.

What the research says: It reliably raises NAD+ levels and was well tolerated for weeks to months in trials, but effects on health and aging have been mixed or absent.

Cautions

• Generally well tolerated in trials; long-term data are limited.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: NR (500 mg per capsule)

Source: PubMed review: NAD+ supplementation for anti-aging: systematic review (2026) (updated February 2026)

Omega-3 (fish oil)

What it is: Fats (EPA and DHA) found in fish that are part of every cell membrane and matter for the heart, brain and eyes.

What the research says: EPA and DHA lower triglycerides. Heart experts recommend eating fish; they don't recommend omega-3 supplements for people at low heart risk.

Cautions

• The FDA advises no more than 5 g a day of EPA plus DHA from supplements.
• Side effects are usually mild: fishy taste, heartburn, nausea, loose stools.

Medicines to check

• Warfarin and other blood thinners: high doses may raise bleeding risk

In Holitro: Omega 3 1000mg (1000 mg per capsule)

Source: NIH Office of Dietary Supplements: Omega-3 Fatty Acids: Fact Sheet for Consumers (updated July 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.