Short answer

We found no documented interaction between NR and Rhodiola in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

NR (nicotinamide riboside)

What it is: A form of vitamin B3 that the body uses to make NAD+, a molecule involved in energy production.

What the research says: It reliably raises NAD+ levels and was well tolerated for weeks to months in trials, but effects on health and aging have been mixed or absent.

Cautions

• Generally well tolerated in trials; long-term data are limited.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: NR (500 mg per capsule)

Source: PubMed review: NAD+ supplementation for anti-aging: systematic review (2026) (updated February 2026)

Rhodiola

What it is: A plant from cold, high-altitude regions, sold for energy, stress, mood and focus.

What the research says: Not enough is known to say it helps with any health purpose.

Cautions

• Possibly safe for up to 12 weeks; it can cause dizziness, headache, insomnia and dry mouth.
• Little is known about use in pregnancy or breastfeeding.

Medicines to check

• Losartan (a blood-pressure drug): interactions have been reported

In Holitro: Rhodiola (250 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Rhodiola: Usefulness and Safety (updated April 2025)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.