Short answer

We found no documented interaction between Rhodiola and Zinc in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Rhodiola

What it is: A plant from cold, high-altitude regions, sold for energy, stress, mood and focus.

What the research says: Not enough is known to say it helps with any health purpose.

Cautions

• Possibly safe for up to 12 weeks; it can cause dizziness, headache, insomnia and dry mouth.
• Little is known about use in pregnancy or breastfeeding.

Medicines to check

• Losartan (a blood-pressure drug): interactions have been reported

In Holitro: Rhodiola (250 mg per capsule)

Source: NIH National Center for Complementary and Integrative Health: Rhodiola: Usefulness and Safety (updated April 2025)

Zinc

What it is: An essential mineral for the immune system, wound healing, taste, and making DNA and proteins.

What the research says: Zinc is needed for normal immune function; it's commonly taken to make sure intake is adequate.

Cautions

• Adults shouldn't exceed 40 mg a day from all sources unless under medical care.
• Too much for a long time can lower copper levels and immunity.
• Very high doses can reduce magnesium absorption.

Medicines to check

• Quinolone and tetracycline antibiotics: take the antibiotic at least 2 hours before or 4 to 6 hours after zinc
• Penicillamine: take at least 1 hour apart
• Thiazide diuretics can lower zinc levels

In Holitro: Zinc (25 mg per capsule)

Source: NIH Office of Dietary Supplements: Zinc: Fact Sheet for Consumers (updated October 2022)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.