Short answer

We found no documented interaction between Triphala and Vitamin B12 in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Triphala

What it is: A traditional Ayurvedic blend of three dried fruits (amalaki, bibhitaki and haritaki), used mainly for digestion.

What the research says: It's traditionally used as a gentle laxative. Most other proposed benefits come from lab and animal studies, not good human trials.

Cautions

• There's little human safety research. Because it acts as a laxative, loose stools are possible.

Medicines to check

• Talk to your clinician if you take any medicine

In Holitro: Triphala (500 mg per capsule)

Source: PubMed review: Therapeutic Uses of Triphala in Ayurvedic Medicine (2017) (updated July 2017)

Vitamin B12

What it is: A vitamin that keeps blood and nerve cells healthy and helps make DNA.

What the research says: B12 prevents a type of anemia that makes people tired and weak. People who take metformin or long-term acid reducers may absorb less of it.

Cautions

• It hasn't been shown to cause harm, even at high doses.

Medicines to check

• Metformin and acid-reducing medicines can lower B12 levels (the medicine affects the vitamin, not the other way round)

In Holitro: Vitamin B12 (1000 mcg per capsule)

Source: NIH Office of Dietary Supplements: Vitamin B12: Fact Sheet for Consumers (updated December 2023)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.