Short answer

We found no documented interaction between Zinc and Vitamin C in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Zinc

What it is: An essential mineral for the immune system, wound healing, taste, and making DNA and proteins.

What the research says: Zinc is needed for normal immune function; it's commonly taken to make sure intake is adequate.

Cautions

• Adults shouldn't exceed 40 mg a day from all sources unless under medical care.
• Too much for a long time can lower copper levels and immunity.
• Very high doses can reduce magnesium absorption.

Medicines to check

• Quinolone and tetracycline antibiotics: take the antibiotic at least 2 hours before or 4 to 6 hours after zinc
• Penicillamine: take at least 1 hour apart
• Thiazide diuretics can lower zinc levels

In Holitro: Zinc (25 mg per capsule)

Source: NIH Office of Dietary Supplements: Zinc: Fact Sheet for Consumers (updated October 2022)

Vitamin C

What it is: An antioxidant vitamin the body needs to make collagen, absorb iron from plant foods and support the immune system.

What the research says: Vitamin C is essential; supplements make sure you get enough if your diet falls short.

Cautions

• Adults shouldn't exceed 2,000 mg a day; too much can cause diarrhea, nausea and cramps.
• People with hemochromatosis should avoid high doses.

Medicines to check

• Chemotherapy and radiation: check with your care team first
• In one study, antioxidants including vitamin C reduced the benefit of a statin plus niacin

In Holitro: Vitamin C (1000 mg per capsule)

Source: NIH Office of Dietary Supplements: Vitamin C: Fact Sheet for Consumers (updated March 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.